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KMID : 0378019730160010049
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New Medical Journal
1973 Volume.16 No. 1 p.49 ~ p.56
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The Study on The Changes in Blood Renin, Aldosterone and Steroids Hormones in Fractured Patients
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Abstract
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Blood Samples of control group was drawn from 10 normal adults and of experimental group was drawn from 8 fractured patients who admitted to hospital after traffic accidents.
From every fractured patient blood samples were taken 3 times, thus, at immediately after accident and at the end of first and fourth week after fractures. and were analyzed for their Na levels,
renin activity, aldosterone and adrenal steroid levels in order to observe variations in blood levels of above hormones during the period of bone repair.
Blood sodium was analyzed by flame photometry, aldosterone and adrenal steroid by chromatography with double isotope derivative assay.
Results obtained were as follows.
1) Renin activity was mean of 1.9±1.2μg/ml/hr in control group and this value increased to 4.62± 1.64 pg/ml/hr immediately after fracture, decreased slightly at one week and increased again to 5.9± 1.87μg/ml/hr in fractured group.
2) Aldosterone level in control group was mean of 0.018pg/100ml of blood and that of fractured group increased remarkably compared with control value. Variation in aldosterone in blood during bone repair follows same course with renin activity.
3) Level of blood steroids averaged at 3.09±1.56μg/100ml of blood in control group. Initial change after fracture showed slight increase and it continuously increased during the period of bone repair showing 9.57±4.65μg/100ml of blood 4 weeks after fracture. From the above data increase of these hormones were common character in fractured patients and these effects suggested the fact that these hormones were closely related with bone metabolism during the period of bone repair.
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